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Article

What can Drosophila tell us about serpins, thrombosis and dementia?

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Jan 2004

Carrell Robin, Corral Javier

Abstract excerpt

The validity of the fruit-fly as a model of human disease has been confirmed in a striking way by Green and colleagues.1 They show that the mutations causing a necrotic disease phenotype in Drosophila, precisely mirror those resulting in a group of well-studied but perplexing diseases in the human. These diseases, ranging from thrombosis to dementia, arise from mutations causing a conformational instability of...

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PMID: 14696034
DOI: 10.1002/bies.10407

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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