Article
Molecular heterogeneity of the fourth component of complement (C4) and its genes in vitiligo.
The Journal of investigative dermatology - 1 Dec 1992
Venneker G T, Westerhof W, de Vries I J, Drayer N M, Wolthers B G, de Waal L P, Bos J D, Asghar S S
Abstract excerpt
In view of evidence suggesting vitiligo is an autoimmune disease, we investigated whether vitiligo is associated with inherited deficiencies of the fourth (C4) and second (C2) component of complement and with certain human leukocyte antigens (HLA). Analysis of functional activities of C4 and C2 in sera of patients with vitiligo (n = 42) showed that 17% of them had a heterozygous C4 deficiency and 5% had a...
Topics
- Adrenal Hyperplasia, Congenital
- Alleles
- Complement C2
- Complement C4
- Family Health
- Female
- Gene Deletion
- HLA Antigens
- Histocompatibility Testing
- Homozygote
- Humans