Article
Effects of electrogenetherapy with p53wt combined with cisplatin on curvival of human tumor cell lines with different p53 status.
DNA and cell biology - 1 Dec 2003
Cemazar Maja, Grosel Alenka, Glavac Damjan, Kotnik Vladimir, Skobrne Mojca, Kranjc Simona, Mir Lluis M, Andre Frank, Opolon Paule, Sersa Gregor
Abstract excerpt
The aim of our study was to evaluate electrogenetherapy with p53wt alone or combined with cisplatin on two colorectal (HT-29 and LoVo) and two prostatic (PC-3 and Du145) carcinoma cell lines with different p53 status. In addition, the feasibility of electrogenetherapy with p53wt was tested also in vivo on PC-3 prostatic cancer xenografts. Electrogenetherapy with p53wt was dependent on the p53 status of the cell...
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