Article
Epigallocatechin-3-gallate, constituent of green tea, suppresses the LPS-induced phenotypic and functional maturation of murine dendritic cells through inhibition of mitogen-activated protein kinases and NF-kappaB.
Biochemical and biophysical research communications - 2 Jan 2004
Ahn Soon-Cheol, Kim Gi-Young, Kim Jin-Hyung, Baik Seong-Wan, Han Myung-Kwan, Lee Hee-Jeong, Moon Dong-Oh, Lee Chang-Min, Kang Ju-Hyung, Kim Bo-Hye, Oh Yang-Hyo, Park Yeong-Min
Abstract excerpt
The effects of epigallocatechin-3-gallate (EGCG) on dendritic cells (DC) maturation were investigated. EGCG, in a dose-dependent manner, profoundly inhibited CD80, CD86, and MHC class I and II expression on bone marrow-derived murine myeloid DC. EGCG restored the decreased dextran-FITC uptake and inhibited enhanced IL-12 production by LPS-treated DC. EGCG-treated DC were poor stimulators of nai;ve allogeneic...
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