Article
Differential accumulation of mutations localized in particular domains of the mucin genes expressed in the vertebrate host stage of Trypanosoma cruzi.
Molecular and biochemical parasitology - 1 Jan 2004
Campo Vanina, Di Noia Javier M, Buscaglia Carlos A, Agüero Fernán, Sánchez Daniel O, Frasch Alberto C C
Abstract excerpt
The surface of Trypanosoma cruzi is covered by mucin-type glycoproteins involved in parasite protection, attachment and immunoevasion. The gene family coding for the mucins expressed by the parasite in the vertebrate host, named TcMUC, is composed of several hundred members and presents high variability. The genes encoding mucins expressed in the insect-dwelling parasite stages are part of a much more homogeneous...
Topics
- Animals
- Base Sequence
- Conserved Sequence
- DNA, Protozoan
- Genes, Protozoan
- Microsatellite Repeats
- Molecular Sequence Data
- Mucins
- Multigene Family
- Mutation