Article
Evidence of sexual recombination among Cryptococcus neoformans serotype A isolates in sub-Saharan Africa.
Eukaryotic cell - 1 Dec 2003
Litvintseva Anastasia P, Marra Robert E, Nielsen Kirsten, Heitman Joseph, Vilgalys Rytas, Mitchell Thomas G
Abstract excerpt
The most common cause of fungal meningitis in humans, Cryptococcus neoformans serotype A, is a basidiomycetous yeast with a bipolar mating system. However, the vast majority (>99.9%) of C. neoformans serotype A isolates possess only one of the two mating type alleles (MATalpha). Isolates with the other allele (MATa) were recently discovered and proven to mate in the laboratory. It has been a mystery whether and...
Topics
- AIDS-Related Opportunistic Infections
- Africa South of the Sahara
- Alleles
- Botswana
- Clone Cells
- Cryptococcosis
- Cryptococcus neoformans
- DNA, Fungal
- Flow Cytometry
- Genes, Fungal
- Genes, Mating Type, Fungal
- Genetic Markers
- Genetic Variation