Article
The crystal structures of EDA-A1 and EDA-A2: splice variants with distinct receptor specificity.
Structure (London, England : 1993) - 1 Dec 2003
Hymowitz Sarah G, Compaan Deanne M, Yan Minhong, Wallweber Heidi J A, Dixit Vishva M, Starovasnik Melissa A, de Vos Abraham M
Abstract excerpt
EDA is a tumor necrosis factor family member involved in ectodermal development. Splice variants EDA-A1 and EDA-A2 differ only by the presence of Glu 308 and Val 309 in the expected receptor binding region of EDA-A1 but not EDA-A2. This two amino acid difference functions as a switch controlling receptor specificity. EDA-A1 binds only to EDAR, while EDA-A2 is specific for XEDAR. In order to understand the...
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