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Article

Gamma-secretase activity of presenilin 1 regulates acetylcholine muscarinic receptor-mediated signal transduction.

The Journal of biological chemistry - 20 Feb 2004

Popescu Bogdan O, Cedazo-Minguez Angel, Benedikz Eirikur, Nishimura Takeshi, Winblad Bengt, Ankarcrona Maria, Cowburn Richard F

Abstract excerpt

Familial Alzheimer's disease (FAD) presenilin 1 (PS1) mutations give enhanced calcium responses upon different stimuli, attenuated capacitative calcium entry, an increased sensitivity of cells to undergo apoptosis, and increased gamma-secretase activity. We previously showed that the FAD mutation causing an exon 9 deletion in PS1 results in enhanced basal phospholipase C (PLC) activity (Cedazo-Minguez, A.,...

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PMID: 14625299
DOI: 10.1074/jbc.M306041200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Gamma-secretase activity of presenilin 1 regulates acetylcholine muscarinic receptor-mediated signal transduction.PMID 14625299Read ↗

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