Article
The CTA1-DD vaccine adjuvant binds to human B cells and potentiates their T cell stimulating ability.
Vaccine - 12 Dec 2003
Eriksson A, Lycke N
Abstract excerpt
The present study demonstrates that the novel CTA1-DD-adjuvant, which combines the full enzymatic activity of the A1 subunit of cholera toxin (CT) with an immunoglobulin-binding domain of Staphylococcus aureus protein A (SpA), binds directly to human peripheral blood B lymphocytes of all classes and greatly augments B cell functions in vitro. These effects were reflected in strongly enhanced co-stimulation,...
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