Article
Genetic susceptibility for lung cancer: interactions with gender and smoking history and impact on early detection policies.
Human heredity - 1 Jan 2003
Gorlova Olga Y, Amos Christopher, Henschke Claudia, Lei Lei, Spitz Margaret, Wei Qingyi, Wu Xifeng, Kimmel Marek
Abstract excerpt
OBJECTIVES: To identify a subgroup of former, current and never smokers (males and females) at high risk for developing lung cancer, based on their genetic susceptibility profiles, to estimate their lifetime probabilities of the disease, and to assess the potential mortality reduction that could be achieved by screening the high-risk group. METHODS: Case-control data (764 cases and 677 matched controls), on two...
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