Article
Functional domains essential for Gs activity in prostaglandin EP2 and EP3 receptors.
Life sciences - 5 Dec 2003
Sugimoto Yukihiko, Nakato Toshiyuki, Kita Ayumi, Hatae Noriyuki, Tabata Hiroyuki, Tanaka Satoshi, Ichikawa Atsushi
Abstract excerpt
The interaction of cell surface hormone receptors with heterotrimeric G proteins is crucial for hormonal actions. The domains of the receptor, which interact with and activate G protein, have been extensively studied. However, precise molecular mechanisms underlying regulation of the receptor-induced G protein activation are still poorly understood. Prostaglandin E(2) (PGE(2)) receptors comprise of four subtypes,...
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