Article
The genetics of adult-onset neuropsychiatric disease: complexities and conundra?
Science (New York, N.Y.) - 31 Oct 2003
Kennedy James L, Farrer Lindsay A, Andreasen Nancy C, Mayeux Richard, St George-Hyslop Peter
Abstract excerpt
Genetic factors play a major role in the etiology of adult-onset neurodegenerative and neuropsychiatric disorders. Several highly penetrant genes have been cloned for rare, autosomal-dominant, early-onset forms of neurodegenerative diseases. These genes have provided important insights into the mechanisms of these diseases (often altering neuronal protein processing). However, the genes associated with inherited...
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