Article
Association between serotonin transporter gene polymorphism and chronic fatigue syndrome.
Biochemical and biophysical research communications - 14 Nov 2003
Narita Masaaki, Nishigami Naoko, Narita Naoko, Yamaguti Kouzi, Okado Nobuo, Watanabe Yasuyoshi, Kuratsune Hirohiko
Abstract excerpt
Interaction between the hypothalamo-pituitary-adrenal axis and the serotonergic system is thought to be disrupted in chronic fatigue syndrome (CFS) patients. We examined a serotonin transporter (5-HTT) gene promoter polymorphism, which affects the transcriptional efficiency of 5-HTT, in 78 CFS patients using PCR amplification of the blood genomic DNA. A significant increase of longer (L and XL) alleic variants...
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