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Article

Risk and prognosis of central nervous system leukemia in patients with Philadelphia chromosome-positive acute leukemias treated with imatinib mesylate.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Oct 2003

Pfeifer Heike, Wassmann Barbara, Hofmann Wolf-Karsten, Komor Martina, Scheuring Urban, Brück Patrick, Binckebanck Anja, Schleyer Eberhard, Gökbuget Nicola, Wolff Thomas, Lübbert Michael, Leimer Lothar, Gschaidmeier Harald, Hoelzer Dieter, Ottmann Oliver G

Abstract excerpt

PURPOSE: In patients with acute leukemias, a lymphoid phenotype, the presence of a Philadelphia chromosome (Ph), and inadequate central nervous system (CNS)-directed prophylactic therapy are risk factors for CNS involvement. Imatinib mesylate has promising single-agent antileukemic activity in patients with advanced Ph(+) acute leukemias. It was the aim of this analysis to determine the incidence of, and risk...

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PMID: 14581336

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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