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Article

Hydrostatic pressure modulates proteoglycan metabolism in chondrocytes seeded in agarose.

Arthritis and rheumatism - 1 Oct 2003

Toyoda Takashi, Seedhom Bahaa B, Yao Jian Q, Kirkham Jennifer, Brookes Steven, Bonass William A

Abstract excerpt

OBJECTIVE: To investigate the effect of isolated hydrostatic pressure on proteoglycan metabolism in chondrocytes. METHODS: Bovine articular chondrocytes cultured in agarose gels were subjected to 5 MPa hydrostatic pressure for 4 hours in either a static or a pulsatile (1 Hz) mode, and changes in glycosaminoglycan (GAG) synthesis, hydrodynamic size, and aggregation properties of proteoglycans and aggrecan...

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Identifiers

PMID: 14558092
DOI: 10.1002/art.11250

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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