Article
A multi-functional organelle mitochondrion is involved in cell death, proliferation and disease.
Current medicinal chemistry - 1 Dec 2003
Ohta Shigeo
Abstract excerpt
The mitochondrion, long considered an organelle specific to energy metabolism, is in fact multi-functional and involved in many diseases. Mitochondrial DNA accumulates somatic mutations during aging, the progression of cancer and diabetes. Most cancer cells contain homoplasmic mutations in the mitochondrial genome. Although little is known about the contributions of mutations to carcinogenesis, some mutations in...
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