Article
Angiogenesis impairment in Id-deficient mice cooperates with an Hsp90 inhibitor to completely suppress HER2/neu-dependent breast tumors.
Proceedings of the National Academy of Sciences of the United States of America - 14 Oct 2003
de Candia Paola, Solit David B, Giri Dilip, Brogi Edi, Siegel Peter M, Olshen Adam B, Muller William J, Rosen Neal, Benezra Robert
Abstract excerpt
Id proteins bind basic helix-loop-helix transcription factors and function as dominant negative inhibitors of gene expression. Id1 and Id3 are required for the recruitment of bone marrow-derived endothelial cell precursors and tumors transplanted into Id-deficient mice demonstrate impaired angiogenesis. Mouse mammary tumor virus-neu mice were bred with Id1-/-Id3+/- mice to ascertain the role of Id1 and Id3 in...
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