Article
Polymorphisms of heme oxygenase-1 and bilirubin UDP-glucuronosyltransferase genes are not associated with Kawasaki disease susceptibility.
The Tohoku journal of experimental medicine - 1 Jul 2003
Kanai Masayo, Tanabe Saori, Okada Masahiko, Suzuki Hiroshi, Niki Takao, Katsuura Michihiko, Akiba Tomoharu, Hayasaka Kiyoshi
Abstract excerpt
Kawasaki disease (KD) is a systemic vasculitis and occurs among Japanese children at a high incidence. Serum bilirubin and heme oxygenase-1 (HO-1) expression are known to play a significant role in the protection of vascular endothelial cells. Japanese have unique polymorphic distribution patterns of (TA)7 or G71R of the bilirubin UDP-glucuronosyltransferase (B-UGT) gene and of (GT)n repeats of the HO-1 gene. We...
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