A single nucleotide polymorphism in the transmembrane domain coding region of HER-2 is associated with development and malignant phenotype of gastric cancer.

doi:10.1002/ijc.11450

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Article

A single nucleotide polymorphism in the transmembrane domain coding region of HER-2 is associated with development and malignant phenotype of gastric cancer.

International journal of cancer - 20 Nov 2003

Kuraoka Kazuya, Matsumura Shunji, Hamai Yoichi, Nakachi Kei, Imai Kazue, Matsusaki Keisuke, Oue Naohide, Ito Reiko, Nakayama Hirofumi, Yasui Wataru

Abstract excerpt

Alterations of the HER-2 (erbB-2/neu) proto-oncogene have been associated with carcinogenesis and poor prognosis of certain cancers. A single nucleotide polymorphism (Ile/Val, A/G) in the transmembrane domain was reported to be associated with a risk of breast cancer. In our study, we examined the association between the HER-2 polymorphism and gastric carcinoma. The Ile/Ile, Ile/Val and Val/Val genotypes were...

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PMID: 14520697
DOI: 10.1002/ijc.11450

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