Article
A crucial role for the vitamin D receptor in experimental inflammatory bowel diseases.
Molecular endocrinology (Baltimore, Md.) - 1 Dec 2003
Froicu Monica, Weaver Veronika, Wynn Thomas A, McDowell Mary Ann, Welsh Jo Ellen, Cantorna Margherita T
Abstract excerpt
The active form of vitamin D (1,25D3) suppressed the development of animal models of human autoimmune diseases including experimental inflammatory bowel disease (IBD). The vitamin D receptor (VDR) is required for all known biologic effects of vitamin D. Here we show that VDR deficiency (knockout, KO) resulted in severe inflammation of the gastrointestinal tract in two different experimental models of IBD. In the...
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