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Methylation imprints of the imprint control region of the SNRPN-gene in human gametes and preimplantation embryos

18 Sept 2003

Abstract excerpt

Imprinting is an epigenetic mechanism leading to mono-allelic expression of imprinted genes. In order to inherit the differential epigenetic imprints from one generation to the next, these imprints have to be erased in the primordial germ cells and re-established in a sex-specific manner during gametogenesis. The exact timing of the imprint resetting is not yet known and the use of immature gametes in assisted...

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PMID: 14500540
DOI: 10.1093/hmg/ddg315

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