Article
Presence of active aliphatic amidases in Helicobacter species able to colonize the stomach.
Infection and immunity - 1 Oct 2003
Bury-Moné Stéphanie, Skouloubris Stéphane, Dauga Catherine, Thiberge Jean-Michel, Dailidiene Daiva, Berg Douglas E, Labigne Agnès, De Reuse Hilde
Abstract excerpt
Ammonia production is of great importance for the gastric pathogen Helicobacter pylori as a nitrogen source, as a compound protecting against gastric acidity, and as a cytotoxic molecule. In addition to urease, H. pylori possesses two aliphatic amidases responsible for ammonia production: AmiE, a classical amidase, and AmiF, a new type of formamidase. Both enzymes are part of a regulatory network consisting of...
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