Article
Construction and characterization of an isogenic urease-negative mutant of Helicobacter mustelae.
Infection and immunity - 1 Sept 1995
Solnick J V, Josenhans C, Suerbaum S, Tompkins L S, Labigne A
Abstract excerpt
Helicobacter mustelae infects the ferret stomach and provides an opportunity to study pathogenic determinants of a Helicobacter species in its natural host. We constructed an isogenic urease-negative mutant of H. mustelae which produced no detectable urease and showed a reduced acid tolerance. This mutant provides an opportunity to further evaluate the role of urease in the pathogenesis of Helicobacter infection.
Topics
- Amino Acid Sequence
- Base Sequence
- DNA Transposable Elements
- Helicobacter
- Hydrogen-Ion Concentration
- Molecular Sequence Data
- Mutation
- Urease