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Article

A non-isotopic in situ hybridisation study of the chromosomal origin of 15 supernumerary marker chromosomes in man.

Journal of medical genetics - 1 Oct 1992

Crolla J A, Dennis N R, Jacobs P A

Abstract excerpt

Fifteen patients presenting with mosaic or non-mosaic karyotypes containing a distamycin-DAPI negative de novo or familial supernumerary marker chromosome were studied with non-isotopic in situ hybridisation using a library of alphoid centromere specific and satellite II/III probes. The in situ hybridisation studies showed that seven markers were derived from satellited autosomes (three chromosome 13/21, two...

Topics

Abnormalities, Multiple
Adult
Amniocentesis
Child, Preschool
Chorionic Villi Sampling
Chromosome Aberrations
DNA Probes
Female
Genetic Markers
Humans
In Situ Hybridization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Infant, Newborn

Intellectual Disability

Male

Phenotype

Pregnancy

Source

Open in PubMed Open full text

Identifiers

PMID: 1433228
DOI: 10.1136/jmg.29.10.699
PMCID: PMC1016126

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1433228-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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