Article
Sporadic hypertrophic cardiomyopathy due to de novo myosin mutations.
The Journal of clinical investigation - 1 Nov 1992
Watkins H, Thierfelder L, Hwang D S, McKenna W, Seidman J G, Seidman C E
Abstract excerpt
Hypertrophic cardiomyopathy occurs as an autosomal dominant familial disorder or as a sporadic disease without familial involvement. While missense mutations in the beta cardiac myosin heavy chain (MHC) gene account for approximately half of all cases of familial hypertrophic cardiomyopathy, the molecular causes of sporadic hypertrophic cardiomyopathy are unknown. To determine whether beta cardiac MHC mutations...
Topics
- Adult
- Aged
- Cardiomyopathy, Hypertrophic
- Female
- Humans
- Male
- Middle Aged
- Mutation
- Myosins