Development of a specific-locus assay in the ad-3 region of two-component heterokaryons of Neurospora: a review.

doi:10.1002/em.2850200402

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Article

Development of a specific-locus assay in the ad-3 region of two-component heterokaryons of Neurospora: a review.

Environmental and molecular mutagenesis - 1 Jan 1992

de Serres F J

Abstract excerpt

In recognition of the need for a more comprehensive data base for genetic risk assessment of human exposure to mutagenic agents in the environment, a model system was developed for specific-locus studies in Neurospora crassa. This lower eukaryotic organism permits the utilization of microbial techniques for recovery of large numbers of specific-locus mutations at two closely linked loci as well as their...

Topics

Adenine
Carbon Dioxide
DNA Mutational Analysis
DNA Repair
DNA, Fungal
Dose-Response Relationship, Drug
Environmental Pollutants
Genes, Fungal
Genetic Complementation Test
Genetic Linkage
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Models, Genetic

Mutagenesis, Site-Directed

Mutagenicity Tests

Neurospora crassa

Point Mutation

Risk Factors

Source

Open in PubMed

Identifiers

PMID: 1425606
DOI: 10.1002/em.2850200402

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1425606-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Development of a specific-locus assay in the ad-3 region of two-component heterokaryons of Neurospora: a review.PMID 1425606Read ↗

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X-ray-induced specific-locus mutations in the ad-3 region of two-component heterokaryons of Neurospora crassa. XII. Analysis of multiple-locus ad-3 mutations reveals a nonrandom distribution of the separate sites of recessive lethal damage throughout the genome.Semantic proximity Read ↗

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Quantitative and qualitative aspects of spontaneous specific-locus mutation in the ad-3 region of heterokaryon 12 of Neurospora crassa.Semantic proximity Read ↗

Quantitative and qualitative comparisons of spontaneous and radiation-induced specific-locus mutation in the ad-3 region of heterokaryon 12 of Neurospora crassa.Semantic proximity Read ↗

Forward-mutation tests on the antitumor agent ICR-170 in Neurospora crassa demonstrate that it induces gene/point mutations in the ad-3 region and an exceptionally high frequency of multiple-locus ad-3 mutations with closely linked sites of recessive lethal damage.Semantic proximity Read ↗

Comparison of the spectra of genetic damage in formaldehyde-induced ad-3 mutations between DNA repair-proficient and -deficient heterokaryons of Neurospora crassa.Semantic proximity Read ↗

Qualitative differences in the spectra of genetic damage in 2-aminopurine-induced ad-3 mutants between nucleotide excision-repair-proficient and -deficient strains of Neurospora crassa.Semantic proximity Read ↗

2-Amino-N6-hydroxyadenine induces gene/point mutations and multiple-locus mutations, but not multilocus deletion mutations, in the ad-3 region of a two-component heterokaryon of Neurospora crassa.Semantic proximity Read ↗

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