Article
2-Amino-N6-hydroxyadenine induces gene/point mutations and multiple-locus mutations, but not multilocus deletion mutations, in the ad-3 region of a two-component heterokaryon of Neurospora crassa.
Mutation research - 1 Aug 1991
de Serres F J, Brockman H E, Overton L K
Abstract excerpt
The mutagenicity of 2-amino-N6-hydroxyadenine (AHA) has been studied in Neurospora crassa by treating a two-component heterokaryon (H-12) and recovering specific-locus mutations induced in the ad-3 region. This assay system permits the identification of ad-3A and/or ad-3B mutants resulting from gene/point mutations, multilocus deletion mutations, and multiple-locus mutations of various genotypes, involving one or...
Topics
- 2-Aminopurine
- Adenine
- Alleles
- Chromosome Deletion
- DNA Damage
- Genetic Complementation Test
- Genotype
- Mutagens
- Neurospora crassa