Article
Novel missense mutation in cardiac beta myosin heavy chain gene found in a Japanese patient with hypertrophic cardiomyopathy.
Biochemical and biophysical research communications - 15 Oct 1992
Nishi H, Kimura A, Harada H, Toshima H, Sasazuki T
Abstract excerpt
We have analyzed the exon 9, 13, 14, 15, and 16 of cardiac beta myosin heavy chain gene in 96 Japanese patients with hypertrophic cardiomyopathy by using PCR-DNA conformation polymorphism analysis. The analysis revealed a sequence variation of the exon 16 in one patient. The sequence variation of...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cardiomyopathy, Hypertrophic
- Codon
- DNA
- Exons
- Humans
- Molecular Sequence Data
- Mutation
- Myocardium
- Myosins
- Oligodeoxyribonucleotides
- Polymerase Chain Reaction
- Sequence Homology, Amino Acid