Activation and detection of (pro)mutagenic chemicals using recombinant strains of Streptomyces griseus.

doi:10.1007/BF02922155

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Article

Activation and detection of (pro)mutagenic chemicals using recombinant strains of Streptomyces griseus.

Applied biochemistry and biotechnology - 1 Jan 2000

Buchholz S E, Omer C A, Viitanen P V, Sariaslani F S, Stahl R G

Abstract excerpt

Two recombinant strains of Streptomyces griseus have been developed to report on the activation of promutagenic chemicals. This activation is monitored by reversion of the bacterial test strains to a kanamycin-resistant phenotype. Strain H69 detects point mutations and was reverted at an increase...

Topics

Genetic Engineering
Genetic Markers
Mutagenicity Tests
Mutagens
Mutation
Phenotype
Plasmids
Streptomyces griseus
Transformation, Genetic

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