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Article

Improved PCR method for detecting monoclonal immunoglobulin heavy chain rearrangement in B cell neoplasms.

1 Sept 1992

Abstract excerpt

AIMS: To develop a simple, optimised, polymerase chain reaction (PCR) based method for detecting the rearranged immunoglobulin heavy chain (IgH). METHODS: Using as primers oligonucleotides (Fr2A, Fr2B) homologous to the conserved sequences to the framework II region and the joining (JH) region, 25 patients with B cell lymphoproliferative disorders, previously characterised by Southern blotting, and three patients...

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Identifiers

PMID: 1401205
DOI: 10.1136/jcp.45.9.770

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Source receipt: pubmed, retrieved 7 Sept 2026.

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