Article
Histomorphological and immunohistochemical evidence that human nodular goiters grow by episodic replication of multiple clusters of thyroid follicular cells.
The Journal of clinical endocrinology and metabolism - 1 Oct 1992
Studer H, Gerber H, Zbaeren J, Peter H J
Abstract excerpt
This study was aimed at dissecting the cellular mechanisms that underly the growth of actively expanding human goiter nodules. Thirty-two nodules from different patients, all removed because of steady recent growth, were serially sectioned and screened for 1) histomorphological signs of cell proliferation and 2) in situ expression of the immunohistochemically stained p21ras protooncogene product. Bovine, porcine,...
Topics
- Adolescent
- Adult
- Aged
- Animals
- Cats
- Cell Division
- Child
- Epithelium
- Female
- Gene Expression
- Goiter, Nodular
- Humans