Article
Autosomal dominant mouse cataract (Lop-10). Consistent differences of expression in heterozygotes.
Investigative ophthalmology & visual science - 1 Oct 1992
Runge P E, Hawes N L, Heckenlively J R, Langley S H, Roderick T H
Abstract excerpt
The clinical and histologic features are reported of an autosomal dominant mouse cataract that was first observed as a new mutation in a cross between BALB/cJ and AKR/J. In the homozygous state, the eyes were microphthalmic, and a dense white cataract was present when the eyes opened at day 12. H...
Topics
- Animals
- Cataract
- Disease Models, Animal
- Gene Expression
- Lens, Crystalline
- Mice
- Mice, Inbred AKR
- Mice, Inbred BALB C
- Microphthalmos
- Mutation