Article
[Study of possible biological transformation of kanamycin to amikacin].
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] - 1 Jun 1992
Vikhanskiĭ Iu D, Iarulin V R, Zhdanovich Iu V, Bartoshevich Iu E, Esipova V V, Nasonova L I
Abstract excerpt
For transformation of kanamycin A (Km) to amikacin (Ak) with acylating enzymes from B. circulans, a culture producing butirosin (Btn), cellular and acellular conversion systems and methods for chemical and biological identification of Km, Ak and Btn were developed. The level of conversion of Km t...
Topics
- Acylation
- Amikacin
- Anti-Bacterial Agents
- Bacillus
- Butirosin Sulfate
- Culture Media
- Hexosamines
- In Vitro Techniques
- Kanamycin
- Mutation