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Camptothecin and 10-hydroxycamptothecin from Camptotheca acuminata hairy roots.

Plant cell reports - 1 Jan 2004

Lorence A, Medina-Bolivar F, Nessler C L

Abstract excerpt

Camptothecin (CPT) is an anticancer and antiviral alkaloid produced by the Chinese tree Camptotheca acuminata (Nyssaceae) and some other species belonging to the families Apocynaceae, Olacaceae, and Rubiaceae. Bark and seeds are currently used as sources for the drug. Several attempts have been made to produce CPT from cell suspensions; however, the low yields obtained limit this approach. Cultures of...

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PMID: 13680137
DOI: 10.1007/s00299-003-0708-4

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