Article
Pigmented variants of Tolypocladium inflatum in relation to cyclosporin A production.
Applied microbiology and biotechnology - 1 Jul 1990
Aarnio T H, Agathos S N
Abstract excerpt
We have isolated four distinct colony types of the fungus Tolypocladium inflatum, the producer of the immunosuppressive agent cyclosporin A: morphologically normal white, red, and orange colonies and morphologically diverse tiny brown colonies. In liquid cultures, white normal and brown colonies developed into yellow broths. The broth of the brown colony had a low final pH and low cyclosporin production, whereas...
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