Article
[The role of the genotype in the cataleptogenic effect of neuroleptics].
Eksperimental'naia i klinicheskaia farmakologiia - 1 Jan 2000
Skrinskaia Iu A, Nikulina E M, Popova N K
Abstract excerpt
The cataleptogenic effects of three neuroleptics from one chemical group was investigated in 8 mice strains (CBA, A/He, C57B1/6, C3H/He, BALB/c, AKR, DD, and CC57Br. Despite significant interstrain, differences in the action of the drugs, haloperidol (0.5 mg/kg) and trifluperidol (0.5 mg/kg) produced much greater cataleptogenic action than fluspirilene (2 mg/kg). At the same time the intensity of catalepsy in...
Topics
- Animals
- Antipsychotic Agents
- Catalepsy
- Dose-Response Relationship, Drug
- Fluspirilene
- Genotype
- Haloperidol
- Male
- Mice
- Mice, Inbred Strains
- Species Specificity
- Trifluperidol