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[The role of the genotype in the cataleptogenic effect of neuroleptics].

Eksperimental'naia i klinicheskaia farmakologiia - 1 Jan 2000

Skrinskaia Iu A, Nikulina E M, Popova N K

Abstract excerpt

The cataleptogenic effects of three neuroleptics from one chemical group was investigated in 8 mice strains (CBA, A/He, C57B1/6, C3H/He, BALB/c, AKR, DD, and CC57Br. Despite significant interstrain, differences in the action of the drugs, haloperidol (0.5 mg/kg) and trifluperidol (0.5 mg/kg) produced much greater cataleptogenic action than fluspirilene (2 mg/kg). At the same time the intensity of catalepsy in...

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PMID: 1363957

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