Article
A detailed linkage map of subtelomeric murine chromosome 12 region including the situs inversus mutation locus IV.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jan 1992
de Meeus A, Alonso S, Demaille J, Bouvagnet P
Abstract excerpt
A mouse model is an invaluable tool to tackle genesis of human congenital diseases that have so far eluded human studies. Homozygote for the i.v. mutation, the murine Si/Col strain presents a left-right lateralization defect of thoracic and abdominal organs and heart defects very similar to human ones. This i.v. mutation has been mapped to the region between the Aat and Igh-C loci, suggesting the presence of an...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.