Article
A detailed linkage map of subtelomeric murine chromosome 12 region including the situs inversus mutation locus IV.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jan 1992
de Meeus A, Alonso S, Demaille J, Bouvagnet P
Abstract excerpt
A mouse model is an invaluable tool to tackle genesis of human congenital diseases that have so far eluded human studies. Homozygote for the i.v. mutation, the murine Si/Col strain presents a left-right lateralization defect of thoracic and abdominal organs and heart defects very similar to human...
Topics
- Animals
- Base Sequence
- Blotting, Southern
- Chromosome Mapping
- Crosses, Genetic
- DNA
- Female
- Genetic Linkage
- Male
- Mice
- Molecular Sequence Data
- Muridae
- Mutation
- Phenotype
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Situs Inversus
- Telomere