Article
Mechanism of skin morphogenesis. II. Retinoic acid modulates axis orientation and phenotypes of skin appendages.
Development (Cambridge, England) - 1 Jul 1992
Chuong C M, Ting S A, Widelitz R B, Lee Y S
Abstract excerpt
The factors that determine the axial orientation and phenotypes of skin appendages were analyzed by studying the effect of retinoic acid (RA) on embryonic chicken skin explant cultures. With RA uniformly distributed in the culture media, the feather buds became smaller, were disoriented or were transformed into scale-like structures in a concentration-dependent manner (from 0.05-2.5 microM). With RA distributed...
Topics
- Animals
- Chick Embryo
- Computer Simulation
- Culture Techniques
- Feathers
- Gene Expression
- Genes, Homeobox
- Immunohistochemistry
- Microscopy, Electron, Scanning
- Models, Biological
- Morphogenesis