Article
The significance of HLA-DRB1 matching in clinical renal transplantation.
Transplantation - 1 Aug 1992
Kobayashi T, Yokoyama I, Uchida K, Tominaga Y, Inoko H, Tsuji K, Takagi H
Abstract excerpt
We analyzed the genotype for HLA-DRB1 alleles by digestion of polymerase chain reaction-amplified genes with the restriction endonucleases (PCR-RFLP) method to investigate the influence of HLA-DR antigen "splits" at the DRB1 gene level on the incidence of acute graft rejection in the renal transplant. For all patients, the incidence of acute rejection was proportional to the number of the serological HLA mismatch...
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