Heterozygosity for apolipoprotein E-4Philadelphia(Glu13----Lys, Arg145----Cys) is associated with incomplete dominance of type III hyperlipoproteinemia.

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Article

Heterozygosity for apolipoprotein E-4Philadelphia(Glu13----Lys, Arg145----Cys) is associated with incomplete dominance of type III hyperlipoproteinemia.

The Journal of biological chemistry - 5 Jul 1992

Lohse P, Rader D J, Brewer H B

Abstract excerpt

Apolipoprotein (apo) E-4Philadelphia is a double mutant of apoE in which residue 13 of the mature protein, glutamic acid (GAG), is replaced by lysine (AAG) and amino acid 145, arginine (CGT), is converted to cysteine (TGT). These mutations result in two restriction fragment length polymorphisms f...

Topics

Adolescent
Adult
Aged
Apolipoprotein E3
Apolipoprotein E4
Apolipoproteins E
Arginine
Child
Cysteine
DNA
Electrophoresis, Polyacrylamide Gel
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Dominant

Glutamates

Glutamic Acid

Heterozygote

Homozygote

Humans

Source

Open in PubMed

Identifiers

PMID: 1352296

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1352296-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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