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Article

Incomplete dominance of type III hyperlipoproteinemia is associated with the rare apolipoprotein E2 (Arg136-->Ser) variant in multigenerational pedigree studies.

Atherosclerosis - 26 Apr 1996

Pocovi M, Cenarro A, Civeira F, Myers R H, Casao E, Esteban M, Ordovas J M

Abstract excerpt

In the process of screening apolipoprotein (apo) E genotypes in a population of subjects with lipid abnormalities, we have identified five subjects (one homozygote and four heterozygotes) with an abnormal 109 base pairs band following apo E restriction isotyping of amplified DNA with the restriction endonuclease CfoI. The polymerase chain reaction (PCR) products were cloned and their sequencing revealed a C-->A...

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Identifiers

PMID: 8724110
DOI: 10.1016/0021-9150(95)06745-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Incomplete dominance of type III hyperlipoproteinemia is associated with the rare apolipoprotein E2 (Arg136-->Ser) variant in multigenerational pedigree studies.PMID 8724110Read ↗

Apolipoprotein E2 (Arg-136-->Cys), a variant of apolipoprotein E associated with late-onset dominance of type III hyperlipoproteinaemia.Semantic proximity Read ↗

Two Italian kindreds carrying the Arg136-->Ser mutation of the Apo E gene: development of premature and severe atherosclerosis in the presence of epsilon 2 as second allele.Semantic proximity Read ↗

Variable expression of hypercholesterolemia in Apolipoprotein E2* (Arg136 --> Cys) heterozygotes.Semantic proximity Read ↗

Identification and characterization of a novel apolipoprotein E variant, apolipoprotein E3' (Arg136-->His): association with mild dyslipidemia and double pre-beta very low density lipoproteins.Semantic proximity Read ↗

Apolipoprotein E2 (Arg136 --> Cys) mutation in the receptor binding domain of apoE is not associated with dominant type III hyperlipoproteinemia.Semantic proximity Read ↗

Rare variant of apolipoprotein E (Arg136 -->Ser) in two normolipidemic individuals.Semantic proximity Read ↗

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Rare variant of apolipoprotein E (Arg136-->Cys) in a subject with normal lipid values.Semantic proximity Read ↗

Rare apolipoprotein E variant identified in a patient with type III hyperlipidaemia.Semantic proximity Read ↗

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Apolipoprotein E gene mutations in subjects with mixed hyperlipidemia and a clinical diagnosis of familial combined hyperlipidemia.Semantic proximity Read ↗

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