Article
Incomplete dominance of type III hyperlipoproteinemia is associated with the rare apolipoprotein E2 (Arg136-->Ser) variant in multigenerational pedigree studies.
Atherosclerosis - 26 Apr 1996
Pocovi M, Cenarro A, Civeira F, Myers R H, Casao E, Esteban M, Ordovas J M
Abstract excerpt
In the process of screening apolipoprotein (apo) E genotypes in a population of subjects with lipid abnormalities, we have identified five subjects (one homozygote and four heterozygotes) with an abnormal 109 base pairs band following apo E restriction isotyping of amplified DNA with the restrict...
Topics
- Adult
- Aged
- Amino Acid Sequence
- Apolipoprotein E2
- Apolipoproteins E
- Female
- Genes, Dominant
- Genetic Variation
- Humans
- Hyperlipoproteinemia Type III
- Male
- Middle Aged
- Mutation
- Pedigree