Studies of the HLA class II alleles involved in human responses to ragweed allergens Ambrosia artemisiifolia V (Ra5S) and Ambrosia trifida V (Ra5G)

doi:10.1111/j.1399-0039.1992.tb01921.x

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Article

Studies of the HLA class II alleles involved in human responses to ragweed allergens Ambrosia artemisiifolia V (Ra5S) and Ambrosia trifida V (Ra5G)

Tissue antigens - 1 Mar 1992

Goldstein R, Yang W H, Drouin M A, Karsh J

Abstract excerpt

Previous studies have associated skin test sensitivity and specific IgE response to Ambrosia artemisiifolia V (Amb a V) with HLA-DR2, and to Ambrosia trifida V (Amb t V) with HLA-DRw52 haplotypes in atopic individuals. Using HLA class II typing by restriction fragment length polymorphism (RFLP) analysis with DRB, DQB and DQA DNA probes to define the HLA-D alleles, we have demonstrated the association of the DQw6...

Topics

Alleles
Allergens
Blotting, Southern
DNA
Genes, MHC Class II
HLA-DR Antigens
HLA-DR Serological Subtypes
HLA-DR2 Antigen
Haplotypes
Humans
Pollen

Polymorphism, Restriction Fragment Length

Rhinitis, Allergic, Seasonal

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