Article
HLA-D locus associations in alopecia areata. DRw52a may confer disease resistance.
Archives of dermatology - 1 Jan 1991
Duvic M, Hordinsky M K, Fiedler V C, O'Brien W R, Young R, Reveille J D
Abstract excerpt
Because predisposition to autoimmunity has been associated with HLA-D alleles and alopecia areata is hypothesized to be a T-cell mediated autoimmune hair loss, we determined DR and DQ alleles in 88 white and 10 American black patients with alopecia areata as well as controls with the use of restriction fragment length polymorphism typing with cDNA probes. White patients with alopecia areata have an increase in...
Topics
- Adolescent
- Adult
- Alopecia Areata
- Autoantibodies
- Child
- Child, Preschool
- DNA Probes
- Disease Susceptibility
- Female
- Genotype
- HLA-D Antigens
- HLA-DQ Antigens