Follow-up of retinoblastoma patients having prenatal and perinatal predictions for mutant gene carrier status using intragenic polymorphic probes from the RB1 gene.

Abstract excerpt

We have carried out presymptomatic prediction of mutant gene carrier status in ten individuals with a family history of retinoblastoma. In all cases standard linkage studies were employed using intragenic DNA probes which recognise restriction fragment length polymorphisms. In four cases foetal D...

Topics

• Base Sequence
• Chorionic Villi Sampling
• DNA
• DNA Probes
• Female
• Fetal Blood
• Follow-Up Studies
• Genes, Retinoblastoma
• Heterozygote
• Humans
• Infant, Newborn
• Molecular Sequence Data
• Mutation
• Pedigree
• Polymorphism, Genetic
• Polymorphism, Restriction Fragment Length
• Predictive Value of Tests
• Pregnancy