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Article

A dementing illness associated with a novel insertion in the prion protein gene.

Brain research. Molecular brain research - 1 Mar 1992

Owen F, Poulter M, Collinge J, Leach M, Lofthouse R, Crow T J, Harding A E

Abstract excerpt

Following our previous report of an 144-bp insertion in the open reading frame of the prion protein (PrP) gene, we have now identified a larger, 216-bp, insertion in the gene. The insertion which is in frame encodes 9 extra octapeptide repeat sequences in addition to the 5 repeats normally present and represents the largest insertion so far detected in the PrP gene.

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Identifiers

PMID: 1349721
DOI: 10.1016/0169-328x(92)90056-h

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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