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Article

A dementing illness associated with a novel insertion in the prion protein gene.

Brain research. Molecular brain research - 1 Mar 1992

Owen F, Poulter M, Collinge J, Leach M, Lofthouse R, Crow T J, Harding A E

Abstract excerpt

Following our previous report of an 144-bp insertion in the open reading frame of the prion protein (PrP) gene, we have now identified a larger, 216-bp, insertion in the gene. The insertion which is in frame encodes 9 extra octapeptide repeat sequences in addition to the 5 repeats normally present and represents the largest insertion so far detected in the PrP gene.

Topics

Alleles
Amino Acid Sequence
Base Sequence
Codon
Creutzfeldt-Jakob Syndrome
DNA Transposable Elements
Female
Genes, Viral
Humans
Middle Aged
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligodeoxyribonucleotides

Open Reading Frames

Polymerase Chain Reaction

PrPSc Proteins

Prions

Source

Identifiers

PMID: 1349721
DOI: 10.1016/0169-328x(92)90056-h

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1349721-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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