Article
Insertions in the prion protein gene in atypical dementias.
Experimental neurology - 1 May 1991
Owen F, Poulter M, Collinge J, Leach M, Shah T, Lofthouse R, Chen Y F, Crow T J, Harding A E, Hardy J
Abstract excerpt
A number of mutations have been demonstrated in the open reading frame (ORF) of the prion protein (PrP) gene in patients with familial Creutzfeldt-Jakob disease or Gerstmann-Sträussler syndrome. On the basis of detecting an insertion in the ORF of the PrP gene in a patient originally suspected to...
Topics
- Alzheimer Disease
- Base Sequence
- Codon
- Creutzfeldt-Jakob Syndrome
- DNA Transposable Elements
- Dementia
- Genes, Viral
- Gerstmann-Straussler-Scheinker Disease
- Humans
- Molecular Sequence Data
- Mutation
- Nucleic Acid Hybridization
- Oligonucleotide Probes
- Open Reading Frames
- PrPSc Proteins
- Prions
- Viral Proteins