Article
Dual mode cytotoxicities of reactive oxygens on L5178Y radiosensitive mutant M10.
Free radical biology & medicine - 1 Oct 1992
Ito A, Shinohara K
Abstract excerpt
Cytotoxic effects of O2- and H2O2 on mammalian cells were investigated in comparison with the relative sensitivity of mouse L5178Y cells and its radiosensitive mutant M10. Both O2- and H2O2 exhibited two different modes of cytotoxic actions depending on their exposure rates: At a high exposure ra...
Topics
- Animals
- Cell Survival
- Dimethyl Sulfoxide
- Hydrogen Peroxide
- Leukemia L5178
- Mice
- Mutation
- Phenanthrolines
- Radiation Tolerance
- Reactive Oxygen Species
- Superoxides
- Tumor Cells, Cultured
- X-Rays