Linkage of hyperkalaemic periodic paralysis in quarter horses to the horse adult skeletal muscle sodium channel gene.

doi:10.1111/j.1365-2052.1992.tb00136.x

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Article

Linkage of hyperkalaemic periodic paralysis in quarter horses to the horse adult skeletal muscle sodium channel gene.

Animal genetics - 1 Jan 1992

Rudolph J A, Spier S J, Byrns G, Hoffman E P

Abstract excerpt

A genetic disease observed in certain Quarter horses is hyperkalaemic periodic paralysis (HYPP). This disease causes attacks of paralysis which can be induced by ingestion of potassium. Recent studies have shown that HYPP in humans is due to single base changes within the adult skeletal muscle sodium channel gene. A large Quarter horse pedigree segregating dominant HYPP was studied to determine if mutations of...

Topics

Animals
Base Sequence
DNA Restriction Enzymes
Female
Genetic Linkage
Genotype
Horse Diseases
Horses
Hyperkalemia
Male
Molecular Sequence Data
Muscles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Paralyses, Familial Periodic

Pedigree

Polymorphism, Genetic

RNA, Messenger

Sodium Channels

Source

Open in PubMed

Identifiers

PMID: 1323940
DOI: 10.1111/j.1365-2052.1992.tb00136.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1323940-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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