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Article

Cloning of a locus involved in Streptococcus mutans intracellular polysaccharide accumulation and virulence testing of an intracellular polysaccharide-deficient mutant.

Infection and immunity - 1 Aug 1992

Harris G S, Michalek S M, Curtiss R

Abstract excerpt

The streptococcal transposon Tn916 (Tcr) was used to isolate mutants of Streptococcus mutans altered in glycogen accumulation to investigate whether glycogenlike intracellular polysaccharides (IPS) play an important role in S. mutans-induced caries formation. S. mutans UA130 (serotype c) was transformed with the Escherichia coli plasmid pAM620 (Tn916), and the resultant transposon libraries were screened for...

Topics

Animals
Chromosome Mapping
Cloning, Molecular
DNA Transposable Elements
Genetic Complementation Test
Glycogen
Mutation
Polysaccharides, Bacterial
Rats
Rats, Inbred F344
Streptococcus mutans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Virulence

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Identifiers

PMID: 1322367
DOI: 10.1128/iai.60.8.3175-3185.1992
PMCID: PMC257299

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1322367-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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