Article
The phosphorylation state of the DegU response regulator acts as a molecular switch allowing either degradative enzyme synthesis or expression of genetic competence in Bacillus subtilis.
The Journal of biological chemistry - 15 Jul 1992
Dahl M K, Msadek T, Kunst F, Rapoport G
Abstract excerpt
Two classes of mutations were identified in the degS and degU regulatory genes of Bacillus subtilis, leading either to deficiency of degradative enzyme synthesis (degS or degU mutations) or to a pleiotropic phenotype which includes overproduction of degradative enzymes and the loss of genetic competence (degS(Hy) or degU(Hy) mutations). We have shown previously that the DegS protein kinase and the DegU response...
Topics
- Alleles
- Bacillus subtilis
- Bacterial Proteins
- Cloning, Molecular
- DNA, Bacterial
- Genes, Bacterial
- Genes, Regulator
- Kinetics
- Models, Biological
- Phosphoprotein Phosphatases